Noortje Kersten

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Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons

May 16, 2024 | biorxiv.org | Nazmiye Ozkan |Max Koppers |Maarten A.F. Altelaar |Noortje Kersten

AbstractLysosomes are membrane-bound organelles critical for maintaining cellular homeostasis. Delivery of biosynthetic lysosomal proteins to lysosomes is crucial to orchestrate proper lysosomal function. However, it remains unknown how the delivery of biosynthetic lysosomal proteins to lysosomes is ensured in neurons, which are highly polarized cells.

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