Maarten A.F. Altelaar

May 29, 2024 | cell.com | Max Koppers |Nazmiye Ozkan |HA NGUYEN |ha nguyễn |Daphne Jurriens |Janine McCaughey | +7 more

Highlights•Axonal ER tubules are required for proper mRNA translation in axons•Nanoscale resolution imaging reveals ribosomes in contact with axonal ER tubules•The axonal ribosome receptor P180 binds specific mRNAs and controls local translation•Axonal ER-ribosome interactions are important for proper neuron developmentSummaryLocal mRNA translation in axons is critical for the spatiotemporal regulation of the axonal proteome.

May 16, 2024 | biorxiv.org | Nazmiye Ozkan |Max Koppers |Maarten A.F. Altelaar |Noortje Kersten

AbstractLysosomes are membrane-bound organelles critical for maintaining cellular homeostasis. Delivery of biosynthetic lysosomal proteins to lysosomes is crucial to orchestrate proper lysosomal function. However, it remains unknown how the delivery of biosynthetic lysosomal proteins to lysosomes is ensured in neurons, which are highly polarized cells.

Feb 29, 2024 | nature.com | Dipti Rai |Victor Yin |Yixin Xu |Eugene A. Katrukha |Maarten A.F. Altelaar |Kai Jiang | +1 more

Abstractγ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins, such as CAMSAPs, but the biochemical cross-talk between minus-end regulation pathways is poorly understood. Here we reconstituted this process in vitro using purified components. We found that all CAMSAPs could bind to the minus ends of γ-TuRC-attached microtubules.

Apr 26, 2023 | mdpi.com | Bohui Li |Maarten A.F. Altelaar |Bas van Breukelen |Van Breukelen

Abstract:Many essential cellular functions are carried out by multi-protein complexes that can be characterized by their protein–protein interactions. The interactions between protein subunits are critically dependent on the strengths of their interactions and their cellular abundances, both of which span orders of magnitude.

Jan 28, 2023 | biorxiv.org | Tim Veth |Albert J.R. Heck |Chiara Francavilla |Maarten A.F. Altelaar

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.