Nergis Imprachim

Feb 14, 2025 | nature.com | Joseph A. Newman |Nergis Imprachim |Paul Clarke |Mohammad Hossain |Hans J. Oh |Paul Workman | +2 more

AbstractBrachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed in healthy tissues, making it a potential therapeutic target. Unfortunately, as a ligandless transcription factor, brachyury has historically been considered undruggable.