Paul Clarke
Group Sport Editor at National World Publishing
Group Sport Editor @NatWorldPub Previously sports content editor and reporter at Reach PLC.
Articles
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Feb 14, 2025 |
nature.com | Joseph A. Newman |Nergis Imprachim |Paul Clarke |Mohammad Hossain |Hans J. Oh |Paul Workman | +2 more
AbstractBrachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. Brachyury is minimally expressed in healthy tissues, making it a potential therapeutic target. Unfortunately, as a ligandless transcription factor, brachyury has historically been considered undruggable.
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Oct 4, 2024 |
pubs.rsc.org | William Paul Unsworth |Paul Clarke |Saikiran Ravi |Christopher J Maddocks
Asymmetric ‘Clip-Cycle’ Synthesis of 3-Spiropiperidines 3-Spiropiperidines can be synthesized in up to 87% yield and 96:4 er using a two step ‘Clip-Cycle’ approach. The ‘Clip’ stage of this method is based on efficient and highly E-selective cross metathesis of N-Cbz-protected 1-amino-hex-5-enes with a thioacrylate. This is followed by the ‘Cycle’ step, in which an intramolecular asymmetric aza-Michael cyclization is promoted by a chiral phosphoric acid catalyst.
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Jul 14, 2023 |
sdcexec.com | Paul Clarke
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