Nicholas C. Vierra

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Articles

Compartmentalized signaling in the soma: Coordination of electrical and protein kinase A signaling at neuronal ER‐plasma membrane junctions

Sep 13, 2024 | onlinelibrary.wiley.com | Nicholas C. Vierra

INTRODUCTION Neurons display extensive compartmentalization of their plasma membrane (PM). This characteristic enables parallel biochemical reactions with sometimes opposing physiological effects to proceed unhindered within the same cell.[1] Specialized membrane compartments in axonal and dendritic processes (boutons and spines, respectively) are prime examples of the extreme PM compartmentalization that confines distinct signaling pathways to specific subcellular sites in neurons.
The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes - Communications Biology

Nov 13, 2023 | nature.com | Collin Matsumoto |Declan Manning |Paula Rhana |Zhihui Fong |Nicholas C. Vierra |James S. Trimmer

AbstractIn arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively. Paradoxically, KV2.1 also plays a sex-specific role by promoting the clustering and activity of CaV1.2 channels. However, the impact of KV2.1 protein organization on CaV1.2 function remains poorly understood.

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