Zhihui Fong

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The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes - Communications Biology

Nov 13, 2023 | nature.com | Collin Matsumoto |Declan Manning |Paula Rhana |Zhihui Fong |Nicholas C. Vierra |James S. Trimmer

AbstractIn arterial myocytes, the canonical function of voltage-gated CaV1.2 and KV2.1 channels is to induce myocyte contraction and relaxation through their responses to membrane depolarization, respectively. Paradoxically, KV2.1 also plays a sex-specific role by promoting the clustering and activity of CaV1.2 channels. However, the impact of KV2.1 protein organization on CaV1.2 function remains poorly understood.

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