Nick Jikomes

Seattle

Neuroscientist (PhD), researcher, writer | Food, drugs, ideas: what you consume influences who you become | My stuff: https://t.co/uEmvIgvBo7

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Articles

Seed Oils, Early-Onset Cancer & Human Metabolic Variability

6 days ago | mindandmatter.substack.com | Nick Jikomes

Not medical advice. The full article is initially available only to paid subscribers, but will become freely available to all within one week of initial publication. This content draws from two M&M podcasts that focus on 2025 studies linking ω-6 PUFAs to cancer.
Linoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229

1 week ago | mindandmatter.substack.com | Nick Jikomes |Nikos Koundouros |John Blenis

Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth. They explore the role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats, the differences between breast cancer subtypes, and the broader implications of dietary balance for health, emphasizing the need for personalized nutrition strategies.
Rhythms, Memory, Time, Place, Representation & the Brain | György Buzsáki | 228

1 week ago | mindandmatter.substack.com | Nick Jikomes |György Buzsáki

Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challenging conventional neuroscience assumptions; the interplay of brain rhythms, sleep, and preconfigured neural dynamics; the history and conceptual foundations of...
Biophysics of Life: Biophotons, Light, Quantum Biology, Regeneration & Cancer | Nirosha Murugan | 227

2 weeks ago | mindandmatter.substack.com | Nick Jikomes

Episode Summary: Dr. Nirosha Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs using silk hydrogels and growth factors; cancer as an energetic dysfunction; the potential of non-invasive photonic...
Psychedelics & Cerebral Cortex: Neuroplasticity, Psilocybin, Ketamine | Alex Kwan | 226

3 weeks ago | mindandmatter.substack.com | Nick Jikomes |Alex C. Kwan

Current time: 0:00 / Total time: -1:17:35Audio playback is not supported on your browser. Please upgrade. Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain. About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.
Nutrition Epidemiology: Fake Science? | John Speakman | 225

3 weeks ago | mindandmatter.substack.com | Nick Jikomes |John Speakman

Current time: 0:00 / Total time: -1:05:49Audio playback is not supported on your browser. Please upgrade. Short Summary: The flaws of nutrition epidemiology with Dr. John SpeakmanAbout the guest: John Speakman, PhD is a professor at the University of Aberdeen and runs a lab in Shenzhen, China, focusing on energy balance, obesity, and aging. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere.
Cancer Biology: Metabolism, Mitochondria & Energy | Thomas Seyfried | 224

1 month ago | mindandmatter.substack.com | Nick Jikomes |Thomas N Seyfried

Current time: 0:00 / Total time: -1:52:21Audio playback is not supported on your browser. Please upgrade. Short Summary: Cancer’s metabolic roots with Dr. Thomas Seyfried. About the guest: Thomas Seyfried, PhD is a professor of biology at Boston College. He has researched cancer metabolism, epilepsy, and lipid biochemistry for over 40 years. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere.
Ketogenic Diet: Cholesterol, Plaque & Heart Heart | Matthew Budoff | 223

1 month ago | mindandmatter.substack.com | Nick Jikomes

Current time: 0:00 / Total time: -58:44Audio playback is not supported on your browser. Please upgrade. Short Summary: Heart health and the ketogenic diet, with expert insights from a cardiologist and researcher. About the guest: Matthew Budoff, MD, is a preventive cardiologist and professor of medicine at UCLA School of Medicine. Note: Podcast episodes are fully available to paid subscribers on the M&M Substack and everyone on YouTube. Partial versions are available elsewhere.
PUFAs & The Palisades: Lipid Peroxidation, Oxidative Stress & Cell Death

1 month ago | mindandmatter.substack.com | Nick Jikomes

Not medical advice. The full article is initially available only to paid subscribers. It will become freely available in full within one week of publication. Large parts of Los Angeles burned to the ground in early 2025. In theory, LA had the material resources and infrastructure necessary to prevent or limit this type of disaster. Despite this, fires of Biblical intensity burned the Palisades and other parts of LA to the ground. The city’s resource management systems were not in healthy balance.
Regenerative Energy & the Light Inside You | Jack Kruse | 221

1 month ago | mindandmatter.substack.com | Nick Jikomes

Short Summary: A mind-bending dive into evolutionary biology and health through a biophysicist’s lens, with Dr. Jack Kruse delivering provocative insights about biology, medicine, and health. About the guest: Jack Kruse, MD, is a neurosurgeon known for integrating biophysics into medicine. He challenges conventional biochemistry with his “leptin prescription” and decentralized health approach.