Mind & Matter Newsletter

What you take in—be it food, medications, or concepts—shapes your identity. Tune in to gain insights from top scientists and thought leaders on how your body and mind respond to different inputs. New episodes are released every week. Please note, this is not medical advice.

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Articles

SSRIs, Sexual Dysfunction, Suicide & Mass Shootings, How FDA Works | David Healy | 232

3 weeks ago | mindandmatter.substack.com | Nick Jikomes

Current time: 0:00 / Total time: -2:10:09Audio playback is not supported on your browser. Please upgrade.
Genetic Variation in Fat Metabolism: Seed Oils, Evolution & Pitfalls in Clinical Studies

3 weeks ago | mindandmatter.substack.com | Nick Jikomes

Not medical advice. Something health gurus routinely say about seed oils: “Well, the clinical evidence is mixed.”Is the evidence mixed? Or are you assuming that every RCT that’s published is well-conducted, measures the appropriate factors, and that all people should respond to a given dietary intervention the same way?
Weekly M&M | May 29, 2025

1 month ago | mindandmatter.substack.com | Nick Jikomes

Newest Episodes: Last episode: “Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication” | Michael Wheeler PhD | [Listen here] Current episode: “Psychedelic Chemistry, Magic Mushrooms, Kratom, Gray Market Research Chemicals, Vape Shops“ | Andrew Chadeayne, PhD | [Listen here] Next episode: “Long-term Pharmaceutical Use, Adverse Drug Reactions & Chronic SSRI Exposure“ | David Healy, MD, PhD | [Listen here] Upcoming Guests: William Bement, PhD (Cell Biologist) - Cytoskeleton &...
Mind & Matter Newsletter | May 22, 2025

1 month ago | mindandmatter.substack.com | Nick Jikomes

Newest Episodes: Last episode: “Linoleic Acid, Seed Oils, mTOR & Breast Cancer“ | Nikos Koundouros, PhD & John Blenis, PhD | [Listen here] Current episode: “Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication” | Michael Wheeler PhD | [Listen here] Next episode: “Psychedelic Chemistry, Magic Mushrooms, Kratom, Gray Market Research Chemicals, Vape Shops“ | Andrew Chadeayne, PhD | [Listen here] Upcoming Guests: TBD Top Articles of 2025 (so far): Bathing in Estrogen: Chemicals in...
Psilocybin & MDMA: Inflammation, Stress & Brain-Body Communication | Michael Wheeler | 230

1 month ago | mindandmatter.substack.com | Nick Jikomes |Michael Wheeler

Wide release date: May 20, 2025Episode Summary: Dr. Michael Wheeler talks about neuroimmune interactions, exploring how the immune system and brain communicate, particularly through the blood-brain barrier and meninges; how chronic stress and inflammation can alter brain circuits, contributing to mood disorders like depression; how drugs like psilocybin and MDMA may reduce inflammation by modulating immune cells in the meninges, offering potential therapeutic benefits.
Seed Oils, Early-Onset Cancer & Human Metabolic Variability

1 month ago | mindandmatter.substack.com | Nick Jikomes

Not medical advice. The full article is initially available only to paid subscribers, but will become freely available to all within one week of initial publication. This content draws from two M&M podcasts that focus on 2025 studies linking ω-6 PUFAs to cancer.
Linoleic Acid, Seed Oils, mTOR & Breast Cancer | Nikos Koundouros & John Blenis | 229

1 month ago | mindandmatter.substack.com | Nick Jikomes |Nikos Koundouros |John Blenis

Episode Summary: New research on how dietary fats, particularly omega-6 fatty acids like linoleic acid, influence triple-negative breast cancer progression by activating the mTOR pathway, a key regulator of cell growth. They explore the role of the FABP5 protein in enhancing cancer cells’ sensitivity to omega-6 fats, the differences between breast cancer subtypes, and the broader implications of dietary balance for health, emphasizing the need for personalized nutrition strategies.
Rhythms, Memory, Time, Place, Representation & the Brain | György Buzsáki | 228

1 month ago | mindandmatter.substack.com | Nick Jikomes |György Buzsáki

Episode Summary: Dr. Gyorgy Buzsaki discusses the hippocampus’s role beyond memory and spatial navigation, delving into its broader functions in cognition, action planning, and brain-body interactions; how hippocampal rhythms, like sharp wave ripples, influence memory consolidation, glucose regulation, and metabolic health, challenging conventional neuroscience assumptions; the interplay of brain rhythms, sleep, and preconfigured neural dynamics; the history and conceptual foundations of...
Biophysics of Life: Biophotons, Light, Quantum Biology, Regeneration & Cancer | Nirosha Murugan | 227

1 month ago | mindandmatter.substack.com | Nick Jikomes

Episode Summary: Dr. Nirosha Murugan discusses the role of biophysics in biology, focusing on how light, particularly biophotons emitted by cells, influences processes like wound healing, neural activity, and cancer detection; how microtubules may act as biological fiber optics, the impact of modern light environments on health; her work inducing limb regeneration in frogs using silk hydrogels and growth factors; cancer as an energetic dysfunction; the potential of non-invasive photonic...
Psychedelics & Cerebral Cortex: Neuroplasticity, Psilocybin, Ketamine | Alex Kwan | 226

2 months ago | mindandmatter.substack.com | Nick Jikomes |Alex C. Kwan

Current time: 0:00 / Total time: -1:17:35Audio playback is not supported on your browser. Please upgrade. Short Summary: Dr. Alex Kwan unpacks the latest neuroscience research on how psychedelics like ketamine & psilocybin reshape the brain. About the guest: Alex Kwan, PhD, is an associate professor of biomedical engineering at Cornell University. His lab employs advanced imaging to study how psychedelics and other drugs affect the mammalian brain.