Nicola Menzies-Gow

Jul 10, 2024 | onlinelibrary.wiley.com | Nicola Menzies-Gow |Edward Knowles

1 INTRODUCTION Laminitis is a common and painful condition of the equine foot that causes significant morbidity and mortality and its management poses a daily challenge in equine practice (Ireland et al., 2011).

Oct 23, 2023 | beva.onlinelibrary.wiley.com | Marine A. Barnabé |Jonathan Elliott |Patricia Harris |Nicola Menzies-Gow

1 INTRODUCTION Equine endocrinopathic laminitis is a common, painful and potentially devastating condition that can affect horses, ponies and donkeys. Although multiple risk factors are recognised, insulin and adiponectin concentrations are currently the most important predictors of endocrinopathic laminitis risk.1, 2 These two hormones are commonly measured in equids, using either serum or plasma obtained via jugular venipuncture.

Oct 6, 2023 | beva.onlinelibrary.wiley.com | Marine A. Barnabé |Jonathan Elliott |Patricia Harris |Nicola Menzies-Gow

1 INTRODUCTION Basal hyperinsulinaemia and hypoadiponectinaemia are independent risk factors for the development of endocrinopathic laminitis.1, 2 Previously laminitic ponies have lower adiponectin concentrations than their never-laminitic counterparts3 and the presence of hypoadiponectinaemia prior to the first development of laminitis suggests that low adiponectin concentrations are not simply a consequence of laminitis.1 Although adiponectin and insulin concentrations are currently...

Oct 6, 2023 | beva.onlinelibrary.wiley.com | Marine A. Barnabé |Jonathan Elliott |Patricia Harris |Nicola Menzies-Gow

1 INTRODUCTION Insulin dysregulation (ID), the key feature of equine metabolic syndrome (EMS), may manifest as tissue insulin resistance (IR), basal hyperinsulinaemia, or an excessive insulin response to hydrolysable carbohydrates.1 Previous studies have shown that continuous infusion of insulin via a euglycaemic–hyperinsulinaemic clamp (EHC) reliably causes endocrinopathic laminitis in healthy equids.2, 3 Although various histological and physiological changes associated with the actions of...

Oct 5, 2023 | beva.onlinelibrary.wiley.com | Nicola Menzies-Gow |Heidi Banse |Aimi Duff |Nicholas Hart

1 INTRODUCTION Pituitary pars intermedia dysfunction (PPID) is a common disease of the older horse and pony.1 Diagnosis and treatment of the condition can be challenging due to either conflicting literature or a lack of evidence. Most of the literature is expert opinion or case series, and there are only two systematic reviews of the accuracy of one available diagnostic test2, 3 and one systematic review of the efficacy of one treatment4 to inform clinical decision-making.