Patricia Harris

Oct 6, 2023 | beva.onlinelibrary.wiley.com | Marine A. Barnabé |Jonathan Elliott |Patricia Harris |Nicola Menzies-Gow

1 INTRODUCTION Basal hyperinsulinaemia and hypoadiponectinaemia are independent risk factors for the development of endocrinopathic laminitis.1, 2 Previously laminitic ponies have lower adiponectin concentrations than their never-laminitic counterparts3 and the presence of hypoadiponectinaemia prior to the first development of laminitis suggests that low adiponectin concentrations are not simply a consequence of laminitis.1 Although adiponectin and insulin concentrations are currently...

Oct 6, 2023 | beva.onlinelibrary.wiley.com | Marine A. Barnabé |Jonathan Elliott |Patricia Harris |Nicola Menzies-Gow

1 INTRODUCTION Insulin dysregulation (ID), the key feature of equine metabolic syndrome (EMS), may manifest as tissue insulin resistance (IR), basal hyperinsulinaemia, or an excessive insulin response to hydrolysable carbohydrates.1 Previous studies have shown that continuous infusion of insulin via a euglycaemic–hyperinsulinaemic clamp (EHC) reliably causes endocrinopathic laminitis in healthy equids.2, 3 Although various histological and physiological changes associated with the actions of...

Sep 8, 2023 | equimanagement.com | Edward Knowles |Patricia Harris |Jonathan Elliott |Yu-Mei Chang

Serum insulin concentration at 60 min (InsulinT60) during an oral sugar test (OST) indicates future laminitis risk and insulin dysregulation (ID). Associations between InsulinT60 and physical and owner-reported variables may help clinicians select individual ponies for ID testing. Associations between InsulinT60 and other metabolic markers may help elucidate ID pathophysiology.

Aug 22, 2023 | beva.onlinelibrary.wiley.com | Edward Knowles |Patricia Harris |Jonathan Elliott |Yu-Mei Chang

1 INTRODUCTION Equine insulin dysregulation (ID) manifests in three forms, namely hyperinsulinaemia, an excessive insulin response to oral sugar/starch and peripheral (tissue) insulin resistance.1 For clinical diagnosis of ID, dynamic tests such as the oral sugar test (OST) are considered to be more sensitive indicators of ID than basal hyperinsulinaemia.1 An association between ID and laminitis is well established.1 Previously we demonstrated that serum insulin concentrations measured in the...