Pablo D. Dans

Oct 29, 2024 | nist.gov | Olivia Love |Rodrigo Galindo-Murillo |Daniel Roe |Pablo D. Dans

Olivia Love, Rodrigo Galindo-Murillo, Daniel Roe, Pablo D. Dans, Thomas E. Cheatham III, Modified nucleic acids have surged as a popular therapeutic route, emphasizing the importance of nucleic acid research in drug discovery and development. Beyond well-known RNA vaccines, antisense oligonucleotides and aptamers can incorporate various modified nucleic acids to target specific biomolecules for various therapeutic activities.

Oct 29, 2024 | dx.doi.org | Olivia Love |Rodrigo Galindo-Murillo |Daniel Roe |Pablo D. Dans

IntroductionClick to copy section linkSection link copied!As the blueprint for all biological functions, nucleic acids (NA) are at the forefront of various research fields, especially the biochemical and pharmaceutical disciplines. Beyond the canonical nucleotides–adenine, cytosine, guanine, and thymine/uracil–there are a significant number of NA modifications, both natural and unnatural or synthetic.