Pacman Szeto

Mar 11, 2023 | nature.com | Pacman Szeto |Miles C Andrews |Ralf B. Schittenhelm

AbstractCellular heterogeneity in cancer is linked to disease progression and therapy response, although mechanisms regulating distinct cellular states within tumors are not well understood. We identified melanin pigment content as a major source of cellular heterogeneity in melanoma and compared RNAseq data from high-pigmented (HPCs) and low-pigmented melanoma cells (LPCs), suggesting EZH2 as a master regulator of these states.