Panagiotis A. Konstantinopoulos

Sep 11, 2023 | nature.com | Michelle Swift |Rui Zhou |Aleem Syed |Panagiotis A. Konstantinopoulos |Alan D. D’Andrea |Yizhou Joseph He

AbstractThe extent and efficacy of DNA end resection at DNA double-strand breaks (DSB) determine the repair pathway choice. Here we describe how the 53BP1-associated protein DYNLL1 works in tandem with the Shieldin complex to protect DNA ends. DYNLL1 is recruited to DSBs by 53BP1, where it limits end resection by binding and disrupting the MRE11 dimer. The Shieldin complex is recruited to a fraction of 53BP1-positive DSBs hours after DYNLL1, predominantly in G1 cells.

Aug 31, 2023 | nature.com | Panagiotis A. Konstantinopoulos

AbstractOvarian cancer is an aggressive disease that is frequently detected at advanced stages and is initially very responsive to platinum-based chemotherapy. However, the majority of patients relapse following initial surgery and chemotherapy, highlighting the urgent need to develop new therapeutic strategies.