Pascal S. Kaeser

May 23, 2024 | nature.com | Aditi Banerjee |Pascal S. Kaeser |Özge D. Özçete

AbstractA wealth of neuromodulatory transmitters regulate synaptic circuits in the brain. Their mode of signaling, often called volume transmission, differs from classical synaptic transmission in important ways. In synaptic transmission, vesicles rapidly fuse in response to action potentials and release their transmitter content. The transmitters are then sensed by nearby receptors on select target cells with minimal delay.