Patrice Newton

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Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications

3 weeks ago | nature.com | Lauren Bird |Bangyan Xu |Andrew Hobbs |Alexander Ziegler |Nichollas E Scott |Patrice Newton | +2 more

AbstractThe obligate intracellular bacterium Coxiella burnetii establishes an intracellular replicative niche termed the Coxiella-containing vacuole (CCV), which has been characterised as a bacterially modified phagolysosome. How C. burnetii withstands the acidic and degradative properties of this compartment is not well understood. We demonstrate that the key lysosomal protease cathepsin B is actively and selectively removed from C.

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