Nichollas E Scott

Oct 23, 2024 | nature.com | Adrianna M Turner |Ian R. Monk |Danielle Ingle |Stephanie Portelli |Torsten Seemann |Liam Sharkey | +7 more

AbstractMultidrug-resistant bacterial pathogens like vancomycin-resistant Enterococcus faecium (VREfm) are a critical threat to human health1. Daptomycin is a last-resort antibiotic for VREfm infections with a novel mode of action2, but for which resistance has been widely reported but is unexplained. Here we show that rifaximin, an unrelated antibiotic used prophylactically to prevent hepatic encephalopathy in patients with liver disease3, causes cross-resistance to daptomycin in VREfm.

Feb 7, 2024 | nature.com | Joshua Hardy |Kira Behrens |Tamanna Saiyed |Leila Jebeli |Nichollas E Scott |Jeffrey J. Babon

AbstractThrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor (TpoR, a homodimeric Class I cytokine receptor) and initiating cell proliferation or differentiation. Here we characterise the murine Tpo:TpoR signalling complex biochemically and structurally, using cryo-electron microscopy. Tpo uses opposing surfaces to recruit two copies of receptor, forming a 1:2 complex.

Jul 19, 2023 | biorxiv.org | Alexander Ziegler |Antoine Dufour |Nichollas E Scott |Laura E Edgington-Mitchell

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Jul 13, 2023 | biorxiv.org | Biswanath Jana |Nichollas E Scott |Evan J Pardue |Mariana Sartorio

Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.