Patrik Bjärterot

Jul 26, 2023 | nature.com | Dominika Luptáková |Yachao He |Theodosia Vallianatou |Per Svenningsson |Erwan Bezard |Patrik Bjärterot

AbstractMetabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non-human primates. However, the complete molecular pathology underlying MPTP-induced parkinsonism remains poorly understood.