Patrik Bjärterot

3 weeks ago | pubs.acs.org | Patrik Bjärterot |Anna Nilsson |Reza Shariatgorji |Theodosia Vallianatou

Analytical ChemistryCite this: Anal. Chem. 2025, XXXX, XXXClick to copy citationCitation copied!. This publication is licensed under CC-BY 4.0 . You are free to share (copy and redistribute) this article in any medium or format and to adapt (remix, transform, and build upon) the material for any purpose, even commercially within the parameters below:Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator.

3 weeks ago | dx.doi.org | Patrik Bjärterot |Anna Nilsson |Reza Shariatgorji |Theodosia Vallianatou

IntroductionClick to copy section linkSection link copied!Metabolomic analysis using mass spectrometry imaging (MSI), through matrix-assisted laser desorption/ionization (MALDI), has emerged as a crucial tool for studying the spatial distribution of metabolites in biological tissues, (1−3) providing insights into the metabolic heterogeneity of tissues. When applied to biological tissues, MALDI-MSI can produce hundreds or even thousands of mass-to-charge (m/z) features in a single experiment.

Jul 26, 2023 | nature.com | Dominika Luptáková |Yachao He |Theodosia Vallianatou |Per Svenningsson |Erwan Bezard |Patrik Bjärterot

AbstractMetabolism of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to the neurotoxin MPP+ in the brain causes permanent Parkinson’s disease-like symptoms by destroying dopaminergic neurons in the pars compacta of the substantia nigra in humans and non-human primates. However, the complete molecular pathology underlying MPTP-induced parkinsonism remains poorly understood.