Erwan Bezard

Aug 20, 2024 | nature.com | Christelle Glangetas |Adriane Guillaumin |Lea Bonamy |Marc Landry |Erwan Bezard |Jerome Baufreton

AbstractThe Insula functions as a multisensory relay involved in socio-emotional processing with projections to sensory, cognitive, emotional, and motivational regions. Notably, the interhemispheric projection from the Insula to the contralateral Insula is a robust yet underexplored connection.

Jul 31, 2024 | nature.com | Rémi Kinet |Marie-Laure Arotcarena |Sylvain Bohic |Erwan Bezard |Pierre-Olivier Fernagut

AbstractLysosomal impairment is strongly implicated in Parkinson’s disease (PD). Among the several PD-linked genes, the ATP13A2 gene, associated with the PARK9 locus, encodes a transmembrane lysosomal P5-type ATPase. Mutations in the ATP13A2 gene were primarily identified as the cause of Kufor-Rakeb syndrome (KRS), a juvenile-onset form of PD. Subsequently, an increasing list of several mutations has been described.

Apr 4, 2024 | movementdisorders.onlinelibrary.wiley.com | Tiago F. Outeiro |Lorraine V. Kalia |Erwan Bezard |Université de Bordeaux

Since the founding of movement disorders as a neurology subspecialty, basic science research has been instrumental for understanding pathophysiology and for advancing the technologies available to diagnose and treat these neurological diseases.

Nov 6, 2023 | nature.com | Tomislav Milekovic |Eduardo Martin Moraud |Charlotte Moerman |Shiqi Sun |Matthew G. Perich |Robin Demesmaeker | +17 more

AbstractPeople with late-stage Parkinson’s disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dorsal root entry zones innervating lumbosacral segments to reproduce the natural spatiotemporal activation of the lumbosacral spinal cord during walking.

Sep 19, 2023 | nature.com | María Trinidad Herrero |Miquel Vila |Erwan Bezard

AbstractAggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed synucleinopathies, which include Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB), and Multiple System Atrophy (MSA). These synucleinopathies are characterized by the deposit of aggregated α-syn in intracellular inclusions observable in neurons and glial cells. In PD and DLB, these aggregates, predominantly located in neurons, are called Lewy Bodies (LBs).