Paul Klenerman

Mar 27, 2024 | nature.com | Daming Zhou |Aiste Dijokaite-Guraliuc |Alexander J. Mentzer |Nigel Temperton |Paul Klenerman |Susanna J. Dunachie | +3 more

AbstractUnder pressure from neutralising antibodies induced by vaccination or infection the SARS-CoV-2 spike gene has become a hotspot for evolutionary change, leading to the failure of all mAbs developed for clinical use. Most potent antibodies bind to the receptor binding domain which has become heavily mutated.