Paul Robinson

Sep 30, 2024 | biorxiv.org | Paul Robinson |Giulia Poloni |Sophie Broadway-Stringer |Lisa Leinhos

AbstractThe ALPK3 gene encodes alpha-protein kinase 3, a cardiac pseudo-kinase of unknown function. Heterozygous truncating variants (ALPK3tv) can cause dominant adult-onset Hypertrophic Cardiomyopathy (HCM). Here we confirm an excess of ALPK3tv in sarcomere-gene negative HCM patients. Moreover, we generated a novel knock-in mouse model carrying an ALPK3tv (K201X). Homozygous animals displayed hypertrophy and systolic dysfunction.

Sep 18, 2024 | thorax.bmj.com | Paul Robinson

Ageing and ivacaftor: unravelling the long-term effects Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Aug 6, 2024 | thorax.bmj.com | Paul Robinson

Cystic FibrosisRespiratory MeasurementPaediatric Lung DisaeseThe cystic fibrosis transmembrane conductance regulator (CFTR) modulator compound, ivacaftor, reached its 10-year anniversary of US Food and Drug Administration (FDA) approval in 2022.

May 23, 2024 | alethonews.com | Paul Robinson

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Feb 22, 2024 | theconversation.com | Nicholas Osborne |Paul Robinson |Dwan Vilcins

Bushfires are currently burning in Australian states including Victoria, Tasmania, Western Australia and South Australia. In some areas, fire authorities have warned residents about the presence of smoke. Bushfire smoke is harmful to our health. Tiny particles of ash can lodge deep in the lungs. Exposure to this type of smoke may worsen existing conditions such as asthma, and induce a range of health effects from irritation of the eyes, nose and throat to changes in the cardiovascular system.