Paul W. Hook

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Articles

Vote Bynum for HD1

Oct 15, 2024 | ketchikandailynews.com | Paul W. Hook

EDITOR, Daily News:I believe Jeremy Bynum is the right choice for our state House of Representatives. Jeremy's tenure as an elected Assembly member for the Ketchikan Gateway Borough has demonstrated his commitment to listening to community members and addressing our concerns. Jeremy demonstrates his commitment to local school funding by crossing over political alliances to offer a solution that funded school activities and pay down the School District's multi-million-dollar debt.
A primordial DNA store and compute engine - Nature Nanotechnology

Aug 22, 2024 | nature.com | Kevin Volkel |Paul W. Hook |Rachel E. Polak |Adriana San Miguel |Winston Timp |James Tuck | +1 more

AbstractAny modern information system is expected to feature a set of primordial features and functions: a substrate stably carrying data; the ability to repeatedly write, read, erase, reload and compute on specific data from that substrate; and the overall ability to execute such functions in a seamless and programmable manner.
Bynum for House District 1

Aug 15, 2024 | ketchikandailynews.com | Paul W. Hook

EDITOR, Daily News:I believe Jeremy Bynum is the right choice for our state House of Representatives. His combination of experience, dedication and community service makes him the ideal candidate to represent us and work toward a brighter future for all Alaskans. I urge you to join me in voting for Jeremy Bynum in the Aug. 20 primary and Nov. 5 general elections!PAULâ€ˆHOOKKetchikan
Nanopore Decoding with Speed and Versatility for Data Storage

Jun 18, 2024 | biorxiv.org | Paul W. Hook |Albert J. Keung |Winston Timp |Kevin Volkel

AbstractAs nanopore technology reaches ever higher throughput and accuracy, it becomes an increasingly viable candidate for reading out DNA data storage. Nanopore sequencing offers considerable flexibility by allowing long reads, real-time signal analysis, and the ability to read both DNA and RNA.
Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignment

Mar 11, 2024 | biorxiv.org | Sam Kovaka |Paul W. Hook |Katharine Jenike |Vikram S. Shivakumar

AbstractNanopore signal analysis enables detection of nucleotide modifications from native DNA and RNA sequencing, providing both accurate genetic/transcriptomic and epigenetic information without additional library preparation. Presently, only a limited set of modifications can be directly basecalled (e.g. 5-methylcytosine), while most others require exploratory methods that often begin with alignment of nanopore signal to a nucleotide reference.
The complete sequence of a human Y chromosome - Nature

Aug 23, 2023 | nature.com | Arang Rhie |Savannah Hoyt |Dylan Taylor |Nicolas Altemose |Paul W. Hook |Sergey Koren | +37 more

AbstractThe human Y chromosome has been notoriously difficult to sequence and assemble because of its complex repeat structure that includes long palindromes, tandem repeats and segmental duplications1,2,3. As a result, more than half of the Y chromosome is missing from the GRCh38 reference sequence and it remains the last human chromosome to be finished4,5.
Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons - BMC Genomics

Jun 7, 2023 | bmcgenomics.biomedcentral.com | Rachel J. Boyd |Sarah A. McClymont |Nelson B. Barrientos |Paul W. Hook |William Law |Rebecca Rose | +4 more

No animals were directly used in this study. All assays were carried out using animal-derived cell lines or publicly available animal-derived cell data. Cell cultureSN4741 cells were obtained from the Ernest Arenas group at the Karolinska Institutet.
Beyond assembly: the increasing flexibility of single-molecule sequencing technology - Nature Reviews Genetics

May 9, 2023 | nature.com | Paul W. Hook |Winston Timp

AbstractThe maturation of high-throughput short-read sequencing technology over the past two decades has shaped the way genomes are studied. Recently, single-molecule, long-read sequencing has emerged as an essential tool in deciphering genome structure and function, including filling gaps in the human reference genome, measuring the epigenome and characterizing splicing variants in the transcriptome.