Peter Halfmann

Sep 25, 2023 | nature.com | Yixuan Hou |Shiho Chiba |Sarah R. Leist |Rita M. Meganck |Alexandra Schafer |Rhianna E. Lee | +7 more

AbstractThe pathogenic and cross-species transmission potential of SARS-CoV-2-related coronaviruses (CoVs) remain poorly characterized. Here we recovered a wild-type pangolin (Pg) CoV GD strain including derivatives encoding reporter genes using reverse genetics. In primary human cells, PgCoV replicated efficiently but with reduced fitness and showed less efficient transmission via airborne route compared with SARS-CoV-2 in hamsters.

Mar 4, 2023 | jci.org | Peter Halfmann |Hejun Liu |Jonathan Torres

AbstractThe rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has emphasized the need to identify antibodies with broad neutralizing capabilities to inform future monoclonal therapies and vaccination strategies.