Peter Horak

2 weeks ago | nature.com | Andreas Mock |Peter Horak |Frederick Klauschen |Melanie Boerries |Simon Kreutzfeldt |Daniel Hübschmann | +6 more

AbstractSalivary gland cancers are rare, diverse malignancies characterized by poor response to immunotherapy. The tumor immune environment in these cancers remains poorly understood. To address this, we perform an integrative analysis of the tumor immune microenvironment in a large cohort of advanced salivary gland cancer samples. Most tumors exhibit low immune activity with limited immune cell infiltration.

Oct 20, 2023 | nature.com | Michael Menzel |Patrick Metzger |Peter Horak |Melanie Boerries |Markus Ball |Olaf Neumann | +11 more

AbstractA growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based detection of copy number alterations (CNAs), and accurate determination of complex biomarkers including tumor mutational burden (TMB), homologous recombination repair deficiency (HRD), and microsatellite instability (MSI).

Oct 20, 2023 | nature.com | Michael Menzel |Patrick Metzger |Peter Horak |Melanie Boerries |Markus Ball |Olaf Neumann | +11 more

AbstractA growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based detection of copy number alterations (CNAs), and accurate determination of complex biomarkers including tumor mutational burden (TMB), homologous recombination repair deficiency (HRD), and microsatellite instability (MSI).