Melanie Boerries

Mar 15, 2024 | nature.com | Celina Tretter |Sebastian Lange |Johannes Untch |Gabriela Zuleger |Mathias Wilhelm |Katja Steiger | +13 more

Correction to: Nature Communications https://doi.org/10.1038/s41467-023-39570-7, published online 02 August 2023 With respect to the original “Data availability” statement, since the publication of this work, to ensure patient data privacy protection per request of the authors’ institute Technical University of Munich, the RNA-seq dataset from sorted CD8+ TILs originally deposited to the European Nucleotide Archive (ENA) with study accession number PRJEB61429 has been transferred to the...

Oct 20, 2023 | nature.com | Michael Menzel |Patrick Metzger |Peter Horak |Melanie Boerries |Markus Ball |Olaf Neumann | +11 more

AbstractA growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based detection of copy number alterations (CNAs), and accurate determination of complex biomarkers including tumor mutational burden (TMB), homologous recombination repair deficiency (HRD), and microsatellite instability (MSI).

Oct 20, 2023 | nature.com | Michael Menzel |Patrick Metzger |Peter Horak |Melanie Boerries |Markus Ball |Olaf Neumann | +11 more

AbstractA growing number of druggable targets and national initiatives for precision oncology necessitate broad genomic profiling for many cancer patients. Whole exome sequencing (WES) offers unbiased analysis of the entire coding sequence, segmentation-based detection of copy number alterations (CNAs), and accurate determination of complex biomarkers including tumor mutational burden (TMB), homologous recombination repair deficiency (HRD), and microsatellite instability (MSI).

Aug 2, 2023 | nature.com | Sebastian Lange |Mathias Wilhelm |Katja Steiger |Sebastian Ochsenreither |Sebastian Bauer |Melanie Boerries | +13 more

Human studyThe study was approved by the institutional review boards (Ethics Commission of the Medical Faculty of Technical University Munich (protocol 193/17S) and Ethics Committee of the Medical Faculty of Heidelberg University (protocol S-206/2011)) and all patients provided written informed consent under these protocols. The study was conducted in accordance with the Declaration of Helsinki.