Peter Wipf

Aug 8, 2024 | nature.com | Purbasha Nandi |Thanh Truong |Peter Wipf |William Paquette |Tsui-Fen Chou |John McCleerey

AbstractHuman p97 ATPase is crucial in various cellular processes, making it a target for inhibitors to treat cancers, neurological, and infectious diseases. Triazole allosteric p97 inhibitors have been demonstrated to match the efficacy of CB-5083, an ATP-competitive inhibitor, in cellular models. However, the mechanism is not well understood.

Jul 17, 2023 | nature.com | Peter Wipf

AbstractCellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result. Previously we reported that tyrosine kinase Fgr is upregulated in ionizing irradiation-induced senescent cells.