Tsui-Fen Chou

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Mechanism of allosteric inhibition of human p97/VCP ATPase and its disease mutant by triazole inhibitors - Communications Chemistry

Aug 8, 2024 | nature.com | Purbasha Nandi |Thanh Truong |Peter Wipf |William Paquette |Tsui-Fen Chou |John McCleerey

AbstractHuman p97 ATPase is crucial in various cellular processes, making it a target for inhibitors to treat cancers, neurological, and infectious diseases. Triazole allosteric p97 inhibitors have been demonstrated to match the efficacy of CB-5083, an ATP-competitive inhibitor, in cellular models. However, the mechanism is not well understood.

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