Purbasha Nandi

Aug 8, 2024 | nature.com | Purbasha Nandi |Thanh Truong |Peter Wipf |William Paquette |Tsui-Fen Chou |John McCleerey

AbstractHuman p97 ATPase is crucial in various cellular processes, making it a target for inhibitors to treat cancers, neurological, and infectious diseases. Triazole allosteric p97 inhibitors have been demonstrated to match the efficacy of CB-5083, an ATP-competitive inhibitor, in cellular models. However, the mechanism is not well understood.

Jan 6, 2024 | biorxiv.org | Zihan Lin |Xiao Zhang |Purbasha Nandi |Yuewei Lin

AbstractX-ray tomography (XRT) and X-ray fluorescence (XRF) imaging are two non-invasive imaging techniques to study cellular structures and chemical element distributions, respectively. However, correlative X-ray tomography and fluorescence imaging for the same cell have yet to be routinely realized due to challenges in sample preparation and X-ray radiation damage.

Aug 4, 2023 | biorxiv.org | Zihan Lin |Xiao Zhang |Purbasha Nandi |Yuewei Lin

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