Philippe Faure

Nov 12, 2024 | nature.com | Jeremie Naude |Sarah Mondoloni |Alexandre Mourot |Philippe Faure

AbstractPhasic variations in dopamine levels are interpreted as a teaching signal reinforcing rewarded behaviors. However, behavior also depends on the motivational, neuromodulatory effect of phasic dopamine. In this study, we reveal a neurodynamical principle that unifies these roles in a recurrent network-based decision architecture embodied through an action-perception loop with the task space, the MAGNet model.

Aug 20, 2024 | biorxiv.org | Fabio Marti |Philippe Faure |Claire Nguyen |Tinaig Le Borgne

AbstractNicotine activates ventral tegmental area (VTA) dopaminergic (DA) neurons projecting to the nucleus accumbens (NAc) to drive its reinforcing effects. Simultaneously, it inhibits those projecting to the amygdala (Amg) to mediate anxiety through a process that remains unknown.