Claire Nguyen

Oct 17, 2024 | nature.com | Lauren Reynolds |Daiana Rigoni |Claire Nguyen |Tinaig Le Borgne |Clara Franco |Fabio Marti | +4 more

AbstractHow nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescent (PND 21-28) male mice was sufficient to produce a marked vulnerability to nicotine in adulthood (PND 60 + ), associated with disrupted functional connectivity in dopaminergic circuits.

Aug 20, 2024 | biorxiv.org | Fabio Marti |Philippe Faure |Claire Nguyen |Tinaig Le Borgne

AbstractNicotine activates ventral tegmental area (VTA) dopaminergic (DA) neurons projecting to the nucleus accumbens (NAc) to drive its reinforcing effects. Simultaneously, it inhibits those projecting to the amygdala (Amg) to mediate anxiety through a process that remains unknown.

May 30, 2023 | elifesciences.org | Sarah Mondoloni |Claire Nguyen |Eleonore Vicq |Maria Ciscato

Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript publishedMay 30, 2023 (This version) AcceptedMay 29, 2023 ReceivedJune 3, 2022 Share this article Cite this article Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus eLife 12:e80767.