Tinaig Le Borgne

Nov 14, 2024 | biorxiv.org | Laia Castell |Angelina Rogliardo |Tinaig Le Borgne |Claire Naon

AbstractSalience attributed to stimuli predicting rewarding or aversive outcomes is critical for adaptive behavior. Dopamine (DA)-neurons play a central role in this process by modulating responses to both rewarding and aversive cues. DA-neurons are tightly and readily modulated by DA D2 autoreceptors (autoD2Rs), but their role in regulating responses to aversive stimuli remains unclear.

Oct 17, 2024 | nature.com | Lauren Reynolds |Daiana Rigoni |Claire Nguyen |Tinaig Le Borgne |Clara Franco |Fabio Marti | +4 more

AbstractHow nicotine acts on developing neurocircuitry in adolescence to promote later addiction vulnerability remains largely unknown, but may hold the key for informing more effective intervention efforts. We found transient nicotine exposure in early adolescent (PND 21-28) male mice was sufficient to produce a marked vulnerability to nicotine in adulthood (PND 60 + ), associated with disrupted functional connectivity in dopaminergic circuits.

Aug 20, 2024 | biorxiv.org | Fabio Marti |Philippe Faure |Claire Nguyen |Tinaig Le Borgne

AbstractNicotine activates ventral tegmental area (VTA) dopaminergic (DA) neurons projecting to the nucleus accumbens (NAc) to drive its reinforcing effects. Simultaneously, it inhibits those projecting to the amygdala (Amg) to mediate anxiety through a process that remains unknown.