Pires DEV

Jul 9, 2024 | onlinelibrary.wiley.com | Kirill Medvedev |R. Schaeffer |Nick V. Grishin |Pires DEV

1 INTRODUCTION Proteins are vital components of cells, playing essential roles in regulating a myriad of cellular processes. The three-dimensional (3D) structure of a protein provides valuable information about protein interactions and functions. Protein domains are functionally, evolutionarily, and structurally distinct units that ensure evolutionary viability by fulfilling specific functions (Buljan & Bateman, 2009; Grishin, 2001).