Nick V. Grishin

Jan 19, 2025 | biorxiv.org | Kirill Medvedev |R. Schaeffer |Nick V. Grishin

AbstractPost-translational modifications (PTMs) play a crucial role in allowing cells to expand the functionality of their proteins and adaptively regulate their signaling pathways. Defects in PTMs have been linked to numerous developmental disorders and human diseases, including cancer, diabetes, heart, neurodegenerative and metabolic diseases. PTMs are important targets in drug discovery, as they can significantly influence various aspects of drug interactions including binding affinity.

Jul 9, 2024 | onlinelibrary.wiley.com | Kirill Medvedev |R. Schaeffer |Nick V. Grishin |Pires DEV

1 INTRODUCTION Proteins are vital components of cells, playing essential roles in regulating a myriad of cellular processes. The three-dimensional (3D) structure of a protein provides valuable information about protein interactions and functions. Protein domains are functionally, evolutionarily, and structurally distinct units that ensure evolutionary viability by fulfilling specific functions (Buljan & Bateman, 2009; Grishin, 2001).

Mar 23, 2024 | biorxiv.org | Kirill Medvedev |R. Schaeffer |Nick V. Grishin

AbstractInteractions between proteins and small organic compounds play a crucial role in regulating protein functions. These interactions can modulate various aspects of protein behavior, including enzymatic activity, signalling cascades, and structural stability. By binding to specific sites on proteins, small organic compounds can induce conformational changes, alter protein-protein interactions, or directly affect catalytic activity.

Aug 12, 2023 | onlinelibrary.wiley.com | Kirill Medvedev |R. Schaeffer |Jimin Pei |Nick V. Grishin

Supporting Information Filename Description pro4750-sup-0001-FigureS1.pdfPDF document, 283.1 KB Figure S1. Missense mutations with benign clinical relevance mapped to kinase domain of Aurora kinase A (PDB: 3E5A). Color shows mutations frequency – from minimum (blue) to maximum (red) pro4750-sup-0002-TableS1.xlsxExcel 2007 spreadsheet , 24.2 KB Supplementary Table S1. Statistics for cancer and non-cancer mutations mapped to Aurora kinase A structure