Kirill Medvedev

Jan 19, 2025 | biorxiv.org | Kirill Medvedev |R. Schaeffer |Nick V. Grishin

AbstractPost-translational modifications (PTMs) play a crucial role in allowing cells to expand the functionality of their proteins and adaptively regulate their signaling pathways. Defects in PTMs have been linked to numerous developmental disorders and human diseases, including cancer, diabetes, heart, neurodegenerative and metabolic diseases. PTMs are important targets in drug discovery, as they can significantly influence various aspects of drug interactions including binding affinity.

Jul 9, 2024 | onlinelibrary.wiley.com | Kirill Medvedev |R. Schaeffer |Nick V. Grishin |Pires DEV

1 INTRODUCTION Proteins are vital components of cells, playing essential roles in regulating a myriad of cellular processes. The three-dimensional (3D) structure of a protein provides valuable information about protein interactions and functions. Protein domains are functionally, evolutionarily, and structurally distinct units that ensure evolutionary viability by fulfilling specific functions (Buljan & Bateman, 2009; Grishin, 2001).

May 2, 2024 | links.org.au | Ilya Budraitskis |Kirill Medvedev |Sasha Davydova

On April 5, 2024, the Russian Socialist Movement (RSM) was declared “foreign agent.” This became the first precedent when the Russian authorities de facto banned a left-wing organization: it is quite obvious that Putin’s oppressive, antidemocratic law eliminates any opportunity for political activity under that name. However, if we see the foreign agent status as a kind of recognition by the regime, it is well deserved.

Mar 23, 2024 | biorxiv.org | Kirill Medvedev |R. Schaeffer |Nick V. Grishin

AbstractInteractions between proteins and small organic compounds play a crucial role in regulating protein functions. These interactions can modulate various aspects of protein behavior, including enzymatic activity, signalling cascades, and structural stability. By binding to specific sites on proteins, small organic compounds can induce conformational changes, alter protein-protein interactions, or directly affect catalytic activity.

Feb 28, 2024 | znetwork.org | Kirill Medvedev |Frederico Fuentes

Moscow-based poet, translator, and activist Kirill Medvedev, of the Russian Socialist Movement (RSD), talks to LINKS International Journal of Socialist Renewal’s Federico Fuentes about the significance of opposition leader Alexei Navalny death in prison, the recent jailing of high-profile anti-war socialist Boris Kagarlitsky and how the international left can campaign against President Vladimir Putin’s repressive regime.