Pirro G. Hysi

Oct 4, 2023 | nature.com | Ashley Budu-Aggrey |Anna Kilanowski |Maria K Sobczyk |Suyash Shringarpure |Ruth E. Mitchell |Kadri Reis | +68 more

AbstractAtopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data.

Sep 23, 2023 | nature.com | Pirro G. Hysi |Janey L. Wiggs

AbstractAlthough glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we investigated associations between mechanosensitive ion channel gene variants and primary open-angle glaucoma (POAG).

Jul 26, 2023 | nature.com | Pirro G. Hysi |Annemarie I. Luik |Karl-Heinz Ladwig |Cristina Menni |M. Arfan Ikram |Karsten Suhre | +8 more

AbstractMetabolome reflects the interplay of genome and exposome at molecular level and thus can provide deep insights into the pathogenesis of a complex disease like major depression.