Janey L. Wiggs

Jan 9, 2024 | nature.com | Andrew Hamel |Wenjun Yan |Xinyi Jiang |Qingnan Liang |Sreekar Mantena |Jiali Wang | +11 more

AbstractPrimary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP.

Jan 3, 2024 | eyetube.net | Arsham Sheybani |Janey L. Wiggs

Genetics in Glaucoma Iqbal Ike K. Ahmed, MD, FRCSC; Arsham Sheybani, MD; and Janey L. Wiggs, MD, PhD Show Description + Janey L. Wiggs, MD, PhD, sits down with Iqbal Ike K. Ahmed, MD, FRCSC, and Arsham Sheybani, MD, to discuss future progress of gene-based therapies for glaucoma. She describes using polygenic risk scores to measure patients’ genetic risk factors for disease and shares thoughts on how these scores could help with earlier treatment intervention.

Sep 23, 2023 | nature.com | Pirro G. Hysi |Janey L. Wiggs

AbstractAlthough glaucoma is a disease modulated by eye pressure, the mechanisms of pressure sensing in the eye are not well understood. Here, we investigated associations between mechanosensitive ion channel gene variants and primary open-angle glaucoma (POAG).