Qian Cong

May 22, 2024 | onlinelibrary.wiley.com | Jimin Pei |Lisa N. Kinch |Qian Cong

1 INTRODUCTION A propeptide, also known as a proprotein, prosegment, prosequence, prodomain or pro region, is a specific segment of a protein's primary structure that is initially synthesized as part of the precursor protein but is later removed to generate the active or mature form.

Oct 14, 2023 | biorxiv.org | R. Schaeffer |Kirill Medvedev |Qian Cong

AbstractProtein structure prediction has now been deployed widely across several different large protein sets. Large scale domain annotation of these predictions can aid in the development of biological insights. Using our Evolutionary Classification of Protein Domains (ECOD) from experimental structures as a basis for classification, we describe the detection and cataloguing of domains from 48 whole proteomes deposited in the AlphaFold Database.

Aug 25, 2023 | onlinelibrary.wiley.com | Jimin Pei |Qian Cong

Supporting Information Filename Description pro4764-sup-0001-Figures.pdfPDF document, 93.3 KB Supplementary Figure S1. The distribution of PAE values of AlphaFold models of human protein kinases. Supplementary Figure S2. The distribution of PAE values for KD-interacting residues predicted to be ordered and those predicted to be disordered.