Qing Shan Ding

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Articles

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

Jan 19, 2024 | science.org | Chiho Kim |Xu-Dong Wang |Zhengshuai Liu |Jianwei Hao |Shuai Wang |Peng Li | +11 more
TIM-4 identifies effector B cells expressing an IL-23-driven proinflammatory cytokine module that promotes immune responses

Sep 23, 2023 | biorxiv.org | Qing Shan Ding |Yufan Wu |Elena Torlai Triglia |Ayshwarya Subramanian

AbstractB cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic Th17 cells. Expression of this proinflammatory module requires B cell expression of IL-23R, RORγt and IL-17.

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