Elena Torlai Triglia

Sep 23, 2023 | biorxiv.org | Qing Shan Ding |Yufan Wu |Elena Torlai Triglia |Ayshwarya Subramanian

AbstractB cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic Th17 cells. Expression of this proinflammatory module requires B cell expression of IL-23R, RORγt and IL-17.

Jun 21, 2023 | nature.com | Yoon-Chul Kye |Elena Torlai Triglia |Alexandra Schnell |Toni Delorey |Kanishka Mohib |Christopher J. Giuliano | +11 more

AbstractThe role of B cells in anti-tumour immunity is still debated and, accordingly, immunotherapies have focused on targeting T and natural killer cells to inhibit tumour growth1,2. Here, using high-throughput flow cytometry as well as bulk and single-cell RNA-sequencing and B-cell-receptor-sequencing analysis of B cells temporally during B16F10 melanoma growth, we identified a subset of B cells that expands specifically in the draining lymph node over time in tumour-bearing mice.