Ayshwarya Subramanian

Oct 16, 2024 | nature.com | Martin W. LaFleur |Rocky M. Barilla |Ayshwarya Subramanian |Yoon-Chul Kye |John G. Doench |Isaac M. Chiu | +2 more

AbstractThe balance between T helper type 1 (TH1) cells and other TH cells is critical for antiviral and anti-tumour responses1,2,3, but how this balance is achieved remains poorly understood. Here we dissected the dynamic regulation of TH1 cell differentiation during in vitro polarization, and during in vivo differentiation after acute viral infection.

Sep 23, 2023 | biorxiv.org | Qing Shan Ding |Yufan Wu |Elena Torlai Triglia |Ayshwarya Subramanian

AbstractB cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic Th17 cells. Expression of this proinflammatory module requires B cell expression of IL-23R, RORγt and IL-17.