Qingfei Zheng

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.