Qiuyin Cai

Apr 11, 2024 | onlinelibrary.wiley.com | Cong Wang |Hui Cai |Qiuyin Cai |Jie Wu

1 INTRODUCTION Pancreatic cancer is the third leading cause of cancer death in the United States, with an overall 5-year survival rate of 12%.1 About half (47%) of pancreatic cancer patients were diagnosed at a late stage with a 5-year survival rate of 3%, due to rapid disease progression and limited treatment options.1 Currently, surgical resection with adjuvant chemotherapy is the only potential cure for pancreatic cancer with an anticipated median overall survival of 54.4 months, but only...

Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more

AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.

Oct 2, 2023 | nature.com | Minta Thomas |Elisabeth Rosenthal |Lori C. Sakoda |Stephanie Schmit |Maria Timofeeva |Ceres Fernández-Rozadilla | +60 more

AbstractPolygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting their utility among these populations.

May 26, 2023 | nature.com | Jianxin Shi |Kouya Shiraishi |Jiyeon Choi |Tzu-Yu Chen |Juncheng Dai |Rayjean J. Hung | +61 more

AbstractLung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci.