R. Paul

May 8, 2024 | medium.com | R. Paul

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Mar 27, 2024 | bmcmicrobiol.biomedcentral.com | R. Paul |APC Microbiome Ireland |College Rd |Co. Cork

Vancomycin-resistant enterococci often represent multi-drug resistance strains and pose a recurring and lethal risk to patients in healthcare facilities. Hypermutable enterococci of clinical interest, such as Enterococcus faecium, often lack CRISPR systems, resulting in the promiscuous acquisition of exogenous DNA and the ability to mutate and persist in challenging niches, such as the healthcare setting.

Feb 22, 2024 | diabetesjournals.org | R. Paul

Reactive oxygen species (ROS) are formed by virtually all tissues. In normal concentrations they facilitate many physiologic activities, but in excess they cause oxidative stress and tissue damage. Local antioxidant enzyme synthesis in cells is regulated by the cytoplasmic KEAP-1/Nrf2 complex, which is stimulated by ROS, to release Nrf2 for entry into the nucleus, where it upregulates antioxidant gene expression.

Dec 7, 2023 | frontiersin.org | APC Microbiome Ireland |R. Paul |Asunción Contreras |Ravinder Nagpal

1 IntroductionThe gut microbiome is the complex community of microorganisms residing in the human gastrointestinal tract, responsible for numerous functions impacting human health and well-being (Rooks and Garrett, 2016; Tropini et al., 2017). Alterations in intestinal microbial composition are associated with a range of diseases, from acute infections to chronic disorders (Guinane and Cotter, 2013; Gilbert et al., 2018; Heilbronner et al., 2021).

Apr 8, 2023 | paperity.org | R. Paul

Drug Delivery and Translational Research, Mar 2023 This is a preview of a remote PDF: https://link.springer.com/content/pdf/10.1007/s13346-023-01332-9.pdf Ryan, Aoibhín, Patel, Pratikkumar, Ratrey, Poonam, O’Connor, Paula M., O’Sullivan, Julie, Ross, R. Paul, Hill, Colin, Hudson, Sarah P.. , Drug Delivery and Translational Research, 2023, pp. 1-17, DOI: 10.1007/s13346-023-01332-9