Rachel L Batterham

Jan 19, 2024 | telegraph.co.uk | Rachel L Batterham

Tackling obesity will reduce the incidence of heart disease and type 2 diabetes Credit: John Locher/AP The economic impact of obesity and excess weight is fast approaching £98 billion, nearly four per cent of GDP. It is surging to become a significant threat to financial stability across the world.

May 15, 2023 | nature.com | Damir Baranasic |Sergio Villicaña |Weihua Zhang |Borzoueh Mohammadi |Colette Christiansen |Richie Soong | +9 more

AbstractDNA methylation variations are prevalent in human obesity but evidence of a causative role in disease pathogenesis is limited. Here, we combine epigenome-wide association and integrative genomics to investigate the impact of adipocyte DNA methylation variations in human obesity. We discover extensive DNA methylation changes that are robustly associated with obesity (N = 190 samples, 691 loci in subcutaneous and 173 loci in visceral adipocytes, P < 1 × 10-7).

Apr 3, 2023 | thelancet.com | Stuart Flint |Rachel L Batterham

Empirical evidence has demonstrated the complex, multifactorial nature of obesity,1Foresight. Tackling obesities: future choices–project report. 2007. where the causes and manifestations of obesity vary from individual-to-individual and thus, there is no one cause or combination of factors that may lead to obesity. As such, we suggest that obesity becomes pluralised (i.e., obesities) to reflect the diverse drivers and manifestations of excess adiposity.