Rakesh K Arya

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Rakesh K Arya |Emily Huang |Megan McMullen

BACKGROUND: The RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but not RIP3, in mediating high fat diet-induced liver injury in mice. RIP1 and RIP3 have active N-terminus kinase domains essential for activation of MLKL and subsequent necroptosis.