Megan McMullen

Jan 12, 2025 | telegraphherald.com | Megan McMullen

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Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Rakesh K Arya |Emily Huang |Megan McMullen

BACKGROUND: The RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but not RIP3, in mediating high fat diet-induced liver injury in mice. RIP1 and RIP3 have active N-terminus kinase domains essential for activation of MLKL and subsequent necroptosis.

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Xiude Fan |Megan McMullen |Tatsunori Miyata

BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (ALD). Although receptor interacting protein kinase 3 (Rip3)-/- mice are completely protected from ethanol-induced liver injury, Mlkl-/- mice are only partially protected.

Dec 4, 2023 | gamedeveloper.com | Megan McMullen

For the past 2 years, I’ve had the opportunity to work on my company’s upcoming indie game. It presented several challenges as I was filling in multiple roles: lead producer and UI artist. Our design struggled to be solidified time and time again as the type of gameplay we were trying to create was a combination of genres, so we had very little to base our concept on. However, it taught me an important lesson regarding leadership and decision making.