Xiaoqin Wu

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Rakesh K Arya |Emily Huang |Megan McMullen

BACKGROUND: The RIP1-RIP3-MLKL-mediated cell death pathway is associated with progression of non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH). Previous work identified a critical role for MLKL, the key effector regulating necroptosis, but not RIP3, in mediating high fat diet-induced liver injury in mice. RIP1 and RIP3 have active N-terminus kinase domains essential for activation of MLKL and subsequent necroptosis.

Nov 6, 2024 | digitalcommons.library.tmc.edu | Xiaoqin Wu |Xiude Fan |Megan McMullen |Tatsunori Miyata

BACKGROUND AND AIMS: Mixed lineage kinase domain-like pseudokinase (MLKL), a key terminal effector of necroptosis, also plays a role in intracellular vesicle trafficking that is critical for regulating liver inflammation and injury in alcohol-associated liver disease (ALD). Although receptor interacting protein kinase 3 (Rip3)-/- mice are completely protected from ethanol-induced liver injury, Mlkl-/- mice are only partially protected.

Aug 23, 2024 | biorxiv.org | Jin Wu |Mingming Gao |Xiaoqin Wu |Yang Liu

AbstractLipid droplets (LDs) are evolutionarily conserved organelles that play important roles in metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. The composition of LD surface phospholipids and their impact on LD growth and function remain to be clearly defined. Phosphoinositides mark cellular organelles and regulate cell signalling and organellar function.

Aug 15, 2023 | mdpi.com | Zhenwei Li |Xiaoqin Wu |Xiaoli Yang

4.4. Results and DiscussionAll experiments in this paper were conducted in the same training environment configuration: AMD 5950X, CPU 64GB RAM, and NVIDIA GeForce RTX3090 24G GPU. PyTorch1.12 framework and Anaconda Python3.7 interpreter built the network framework. The weight decay is 1 × 10−4; the total epoch is 100 times; the initial learning rate is 3 × 10−4; the batch size is 4; and the activation function is Softmax.

Mar 29, 2023 | mdpi.com | Tao Xu |Kai Zheng |Xiaoqin Wu

Abstract:This study aimed to investigate the relationship among risk perception, negative emotions, perceived government coping validity, and the sleep problem of the public, through regression analysis and mediation analysis of data from the early stages of the COVID-19 outbreak in China (three months after the outbreak).