Ramon Gonzalez

Jul 20, 2024 | nature.com | Yasuo Yoshikuni |Tobias J Erb |Ramon Gonzalez |Karolina Michalska |Natalia Maltseva |Philipp Wichmann | +1 more

Abstract2-Hydroxyacyl-CoA lyase/synthase (HACL/S) is a thiamine diphosphate (ThDP)-dependent versatile enzyme originally discovered in the mammalian α-oxidation pathway. HACL/S natively cleaves 2-hydroxyacyl-CoAs and, in its reverse direction, condenses formyl-CoA with aldehydes or ketones. The one-carbon elongation biochemistry based on HACL/S has enabled the use of molecules derived from greenhouse gases as biomanufacturing feedstocks.

Feb 5, 2024 | arxiv.org | Ramon Gonzalez

arXiv:2402.02965 (math) [Submitted on 5 Feb 2024 (v1), last revised 28 Feb 2024 (this version, v2)] Download PDF HTML (experimental) Comments: Subjects: Rings and Algebras (math.RA) Cite as: arXiv:2402.02965 [math.RA] (or arXiv:2402.02965v2 [math.RA] for this version) https://doi.org/10.48550/arXiv.2402.02965 Submission history From: Ramon Gonzalez Rodriguez [ view email] [v1] Mon, 5 Feb 2024 12:44:29 UTC (17 KB) [v2] Wed, 28 Feb 2024 16:44:28 UTC (17 KB) Bibliographic Tools Bibliographic...