Reinhard Büttner

Mar 13, 2024 | nature.com | Julie George |Lukas Maas |Nima Abedpour |Laura S. Kaiser |Andreas Scheel |Martin Hellmich | +11 more

AbstractThe evolutionary processes that underlie the marked sensitivity of small cell lung cancer (SCLC) to chemotherapy and rapid relapse are unknown1,2,3. Here we determined tumour phylogenies at diagnosis and throughout chemotherapy and immunotherapy by multiregion sequencing of 160 tumours from 65 patients.

Feb 17, 2023 | nature.com | Jana Fassunke |Sandra Ackermann |Martin Peifer |Reinhard Büttner |Johannes H. Schulte |Thorsten Simon | +1 more

AbstractBackgroundGenomic alterations of the anaplastic lymphoma kinase gene (ALK) occur recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system. However, information on their development over time has remained sparse. MethodsALK alterations were assessed in neuroblastomas at diagnosis and/or relapse from a total of 943 patients, covering all stages of disease.