Johannes H. Schulte

Aug 21, 2024 | nature.com | Jeff Didier |Sébastien De Landtsheer |Anna-Marie Finger |Johannes H. Schulte |Thomas C Sauter |Achim Kramer

AbstractThe circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as promising avenues. Aligning drug administration with the circadian rhythm can enhance treatment efficacy and minimize side effects. Yet, uncovering the optimal treatment timings remains challenging, limiting their widespread adoption.

Jun 12, 2024 | lexology.com | Johannes H. Schulte

Ein Überblick zum Entwurf des Wasserstoffbeschleunigungsgesetzes vom 29.05.2024Das Bundeskabinett hat am 29.05.2024 den „Entwurf eines Gesetzes zur Beschleunigung der Verfügbarkeit von Wasserstoff und zur Änderung weiterer rechtlicher Rahmenbedingungen für den Wasserstoffhochlauf sowie zur Änderung weiterer energierechtlicher Vorschriften“ auf den Weg gebracht.

Mar 7, 2023 | nature.com | Bieke Decaesteker |Siebe Loontiens |Fanny De Vloed |Juliette Roels |Jo Van Dorpe |Christophe Van Neste | +11 more

Samples and cell linesCopy number analysis was performed on primary untreated NB tumors, representative of all genomic subtypes including 263 and 223 samples11,12 of the NRC cohort (GSE8504717), 556 samples of the NB high-risk cohort (GSE10312310), and one unpublished in-house sample. In addition, copy number data of 33 NB cell lines11 and the cell line COG-N-373 (Fig. 1a) were used.

Feb 17, 2023 | nature.com | Jana Fassunke |Sandra Ackermann |Martin Peifer |Reinhard Büttner |Johannes H. Schulte |Thorsten Simon | +1 more

AbstractBackgroundGenomic alterations of the anaplastic lymphoma kinase gene (ALK) occur recurrently in neuroblastoma, a pediatric malignancy of the sympathetic nervous system. However, information on their development over time has remained sparse. MethodsALK alterations were assessed in neuroblastomas at diagnosis and/or relapse from a total of 943 patients, covering all stages of disease.