Ricardo Wurmus

Sep 21, 2023 | nature.com | Ivano Legnini |Agnieszka Rybak-Wolf |Ricardo Wurmus |Anastasiya Boltengagen |Stefan Kempa |Andrew Woehler | +3 more

AbstractOrganoids derived from stem cells have become an increasingly important tool for studying human development and modeling disease. However, methods are still needed to control and study spatiotemporal patterns of gene expression in organoids. Here we combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.